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KMID : 0387820220290020084
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Clinical Pediatric Hematology-Oncology
2022 Volume.29 No. 2 p.84 ~ p.88
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EBV Associated Lymphomatoid Granulomatosis in 18-Year-Old Male: A Case Report
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Jung Eun-Sun
Bae Eun-Young
Roh Eui-Jeong
Chung Eun-Hee
You Sun-Kyoung
Kim Jin-Man
Kim Min-Ji
Lim Yeon-Jung
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Abstract
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Lymphomatoid granulomatosis (LYG) is an Epstein-Barr virus (EBV)-associated lym-phoproliferative disease. It is considered a rare entity in pediatric patients. An ado-lescent male with lobar consolidation suspected of having pneumonia was resistant to antibiotics and had persistently abnormal radiographs with chest pain. The patient was diagnosed with pulmonary LYG through video-assisted thoracoscopic surgery (VATS) lung biopsy. He received eight cycles of rituximab, vincristine, cyclo-phosphamide, and prednisolone (R-CVP) but had progressive disease. As the patient developed hypogammaglobulinemia after eight courses of rituximab, he received in-travenous gamma globulin (IVIG) at regular interval. With immune augmentation ef-fect of IVIG and immune modulation treatment with prednisolone, the patient has shown no aggravation of the lung lesions. Considering its rarity, high mortality, and frequent relapses, diagnostic methods investigating the radiologic abnormalities can help in early treatment initiation.
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KEYWORD
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Lymphomatoid granulomatosis, Adolescent, Video-assisted thoracoscopic surgery, Epstein-Barr virus, Rituximab
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